Mouse Anti-RAN antibody_Primary Antibody_Antibody_SUNLONG BIOTECH CO., LTD-杭州圣隆生物科技有限公司

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Mouse Anti-RAN antibody

Total

Product Summary

NO.:SLM-60438M

Clonality:Monoclonal

Immunogen Species:Mouse

React Species:Human,Mouse,Rat

Applications:WB,IHC-P,IHC-F,ICC/IF,IF

concentration:1mg/ml

Manual

Product Spec:

50ul

100ul

Number:

Details

Product Name	RAN

Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	H6E1
React Species	Human,Mouse,Rat
Applications	WB=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500（Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG2b/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	GTPases are involved in nucleocytoplasmic transport, participating in the import and export of proteins and RNA from the nucleus. They switch between the cytoplasmic GDP-bound state and the nuclear GTP-bound state through nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin β bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, whereas export receptors behave in the opposite manner. Therefore, RAN controls the cargo loading and release of transport receptors in appropriate compartments and ensures the directionality of transport. The interaction with RANBP1 can cause a conformational change in the complex formed by XPO1 and RAN, thereby triggering the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly on mitotic chromosomes and is essential for normal mitotic spindle assembly and chromosome segregation. It is necessary for the normal progression of mitosis.

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