Mouse Anti-GCK antibody_Primary Antibody_Antibody_SUNLONG BIOTECH CO., LTD-杭州圣隆生物科技有限公司

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Mouse Anti-GCK antibody

Total

Product Summary

NO.:SLM-60494M

Clonality:Monoclonal

Immunogen Species:Mouse

React Species:Human,Mouse,Rat

Applications:WB,IHC-P,IHC-F,ICC/IF,IF

concentration:1mg/ml

Manual

Product Spec:

50ul

100ul

Number:

Details

Product Name	GCK

Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	G12H9
React Species	Human,Mouse,Rat
Applications	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:50-200,IF=1:100-500（Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Catalyzes the phosphorylation of hexoses (such as D-glucose, D-fructose, and D-mannose) to hexose 6-phosphates (D-glucose 6-phosphate, D-fructose 6-phosphate, and D-mannose 6-phosphate, respectively). Compared with other hexokinases, hexokinase has a lower affinity for D-glucose and is only effective when glucose is abundant. It is mainly expressed in pancreatic β-cells and the liver, where it constitutes the rate-limiting step of glucose metabolism in these tissues. Since insulin secretion is parallel to glucose metabolism, and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in pancreatic β-cells. In the pancreas, it plays an important role in regulating insulin secretion. In the liver, it helps promote the absorption and conversion of glucose and serves as an insulin-sensitive determinant for hepatic glucose utilization. D-glucose 6-phosphate is required for glycogen synthesis. It mediates the initial step of glycolysis by catalyzing the phosphorylation of D-glucose to D-glucose 6-phosphate.

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