Product types

Flow cytometry antibody

English aliases

CD8; CD8alpha; IMD116; Leu2; p32; Ly-2; Ly-35; Ly-B; Lyt-2; CD8A_HUMAN; CD8A; T-lymphocyte differentiation antigen T8/Leu-2; MAL; CD8A_MOUSE; T-cell surface glycoprotein Lyt-2; Lyt2; G1SX34_RABIT; CD8 subunit alpha; CD8 antigen, alpha polypeptide (p32); T-cell surface glycoprotein CD8 alpha chain; CD8a molecule

Product applications

Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.

Cross-reaction

Mouse

Antibody sources

Rat

Related markings

APCAPC-Cy5.5APC-Cy7BF350BF405BF488BF555BF594BF647BF680BF700BF750BiotinCy3Cy5Cy5.5Cy7FITCPacific BluePEPE-Cy5PE-Cy5.5PE-Cy7PerCPPerCP-Cy5.5PerCP-Cy7RBITC

Subtype

Rat IgG2a, k

Characteristics

Liquid

Purification methods

affinity purified by Protein G

Types of cloning

Monoclonal

and was honored with a title

6B2

Theoretical molecular weight

27 kDa

Molecular weight detection

32 kDa

Storage liquid

0.01M TBS (pH7.4).

Storage conditions

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Notes

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Database link

Entrez Gene : 925 Human

Entrez Gene : 12525 Mouse

SwissProt : P01732 Human

SwissProt : P01731 Mouse

SwissProt : G1SX34 Rabbit

Background information

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]