Product types

Flow cytometry antibody

English name

mouse CD3 Rat mAb

English aliases

CD3epsilon; IMD18; T3E; TCRE; CD3; CD3E_HUMAN; CD3E; T-cell surface antigen T3/Leu-4 epsilon chain; CD3E_MOUSE; CD3 epsilon subunit of T-cell receptor complex; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3e molecule; T-cell surface glycoprotein CD3 epsilon chain

Product applications

Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.

Cross-reaction

Mouse

Antibody sources

Rat

Related markings

APCAPC-Cy7BF405FITCPEPerCPPerCP-Cy5.5

Subtype

Rat IgG2b, k

Characteristics

Liquid

Purification methods

affinity purified by Protein G

Types of cloning

Monoclonal

and was honored with a title

2B5

Theoretical molecular weight

20 kDa

Molecular weight detection

20 kDa

Storage liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage conditions

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Notes

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Database link

Entrez Gene : 916 Human

Entrez Gene : 12501 Mouse

Omim : 186830 Human

SwissProt : P07766 Human

SwissProt : P22646 Mouse

Unigene : 3003 Human

Unigene : 210361 Mouse

Background information

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.