Details
| Product Name | Anti-EPX/AP |
| Chinese Name | 碱性磷酸酶（AP）标记的嗜酸性粒细胞过氧化物酶抗体 |
| Alias | Eosinophil peroxidase; Eosinophil peroxidase heavy chain; EPER; EPO; EPP; EPX PEN; PERE; PERE_HUMAN. |
| Research Area | Tumour immunology |
| Immunogen Species | Rabbit |
| Clonality | Polyclonal |
| React Species | Mouse(predicted:Human,Rat) |
| Applications | IHC-P=1:100-500,IHC-F=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| Molecular weight | 79kDa |
| Form | Lyophilized or Liquid |
| Concentration | 1mg/ml |
| immunogen | KLH conjugated synthetic peptide derived from human Eosinophil peroxidase heavy chain |
| Lsotype | IgG |
| Purification | affinity purified by Protein A |
| Storage Buffer | 1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol. |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 1M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Product Detail |
background: EPX, eosinophil peroxidase, is an antimycobacterial protein that localizes to cytoplasmic granules of eosinophils and recruits bromide to generate a halogenating oxidant. EPX dependent generation of hypobromous acid causes damage to tissue during inflammatory conditions that include asthma, allergies,cancer and parasitic/helminthic infections. EPX is a major enzyme present in eosinophils and upon degranulation, becomes released into the airways of asthmatics. As a result of its cationic nature and its ability to catalyze the formation of highly toxic oxidants, EPX can induce lung injury in a JNK dependent manner. Function: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. Subunit: Tetramer of two light chains and two heavy chains. Subcellular Location: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils. DISEASE: Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [MIM:261500]. EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining. Similarity: Belongs to the peroxidase family. XPO subfamily. Database links: UniProtKB/Swiss-Prot: P11678.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
Partial purchase records (5)
| Username | Quantity | bought time |
| Ha*** | 2 | 2024-08-27 |
| Ev*** | 1 | 2024-03-01 |
| Vi*** | 1 | 2024-02-21 |
| Ol*** | 1 | 2024-01-24 |
| Zo*** | 1 | 2023-06-18 |
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