Details
| Product Name | KY |
| Chinese Name | 脊柱侧后凸畸形肽酶抗体 |
| Alias | KY; KY_HUMAN; Kyphoscoliosis peptidase. |
| Research Area | Developmental biology Neurobiology Cell adhesion molecule |
| Immunogen Species | Rabbit |
| Clonality | Polyclonal |
| React Species | (predicted: Human, Mouse, Rat, Dog, Pig, ) |
| Applications | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 （Paraffin sections need antigen repair）
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| Theoretical molecular weight | 75kDa |
| Cellular localization | cytoplasmic |
| Form | Liquid |
| Concentration | 1mg/ml |
| immunogen | KLH conjugated synthetic peptide derived from mouse Kyphoscoliosis peptidase: 51-150/661 |
| Lsotype | IgG |
| Purification | affinity purified by Protein A |
| Buffer Solution | 1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol. |
| Storage | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| Attention | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| Product Detail |
KY peptidase (Kyphoscoliosis peptidase) is a 561 amino acid cytoskeleton protease that interacts with several sarcomeric cytoskeletal proteins, including Filamin 2. KY peptidase probably plays a role in the maturation, function and stabilization of the neuromuscular junction. KY-null mouse mutants exhibit distinct irregular subceullular Filamin 2 localization, suggesting that KY peptidase deficiency may be the cause of several types of limb-girdle muscular dystrophies. Function: Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC. Subunit: Interacts with IGFN1 and FLNC. Subcellular Location: Cytoplasm Tissue Specificity: Specifically expressed in skeletal and cardiac muscle. Similarity: Belongs to the transglutaminase-like superfamily. SWISS: Q8NBH2 Gene ID: 339855 Database links: Entrez Gene: 339855 Human Entrez Gene: 16716 Mouse Omim: 605739 Human SwissProt: Q8NBH2 Human SwissProt: Q8C8H8 Mouse Unigene: 146730 Human |
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