Rabbit Anti-Acetyl-Histone H4 (Lys8)antibody_Primary Antibody_Antibody_SUNLONG BIOTECH CO., LTD-杭州圣隆生物科技有限公司

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Rabbit Anti-Acetyl-Histone H4 (Lys8)antibody

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Product Summary

NO.:SL60034R

Clonality:Polyclonal

Immunogen Species:Rabbit

React Species:Human,Mouse,Rat

Applications:WB,IHC-P,IHC-F,ICC/IF,IF

concentration:1mg/ml

Manual

Product Spec:

50ul

100ul

Number:

Details

Product Name	Acetyl-Histone H4 (Lys8)

Product Type	Acetylated anti
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,Mouse,Rat
Applications	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:50-200,IF=1:100-500（Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG
Purification	Antigen affinity purification
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Post-translational modifications (PTMs) of histones are key mechanisms in the regulation of chromatin structure by epigenetics and are known as the "histone code". PTMs on histones, including acetylation, methylation, phosphorylation, and new acylation, directly affect the accessibility of chromatin to transcription factors and other epigenetic regulations, altering genome stability, gene transcription, etc. Histone acetylation mainly occurs on multiple lysine residues at the amino-terminal of core histones in response to various stimuli, and plays an important role in gene expression regulation, DNA damage repair, chromatin dynamics, etc. In most cases, histone H2A is mainly acetylated at Lys5, 9, 15, and 36. H2B is mainly acetylated at Lys5, 12, 15, 16, and 20. Histone H3 is mainly acetylated at Lys4, 9, 14, 18, 23, 27, 56, and 79. Histone H4 is mainly acetylated at Lys5, 8, 12, 16, and 20. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are the main regulatory factors.

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